Acute T-cell lymphoblastic leukemia: chimeric antigen receptor technology may offer a new hope

Acute T-cell lymphoblastic leukemia: chimeric antigen receptor technology may offer a new hope

Blog Article

Acute lymphoblastic leukemia (ALL) is a prevalent malignancy affecting the hematopoietic system, Dice encompassing both B-cell ALL (B-ALL) and T-cell ALL (T-ALL).T-ALL, characterized by the proliferation of T-cell progenitors in the bone marrow, presents significant treatment challenges, with patients often experiencing high relapse rates and poor long-term survival despite advances in chemotherapy and hematopoietic stem cell transplantation (HSCT).This review explores the pathogenesis and traditional treatment strategies of T-ALL, emphasizing the promising potential of chimeric antigen receptor (CAR) technology in overcoming current therapeutic limitations.

CAR therapy, leveraging genetically modified immune cells to target leukemia-specific antigens, offers a novel and precise approach to T-ALL treatment.The review critically analyzes recent helmets developments in CAR-T and CAR-NK cell therapies, their common targets, optimization strategies, clinical outcomes, and the associated challenges, providing a comprehensive overview of their clinical prospects in T-ALL treatment.